FINE-NEEDLE ASPIRATION CYTOLOGY OF LANGERHANS CELL HISTIOCYTOSIS INVOLVING THE THYROID - A CASE-REPORT

We present an unusual case of Langerhans cell histiocytosis (LCH) invo lving the thyroid gland initially diagnosed by fine needle aspiration biopsy in a 16-year-old boy. The cytologic findings in LCH involving t he thyroid include high cellularity, isolated Langerhans cells with pr ominent nuclear grooves, multinucleate Langerhans cells, eosinophils, lymphocytes and rare benign follicular cells. Confirmation of LCH was obtained by cove biopsy, positive S-100 protein immunohistochemical st aining and the demonstration of Bir beck granules on electron microsco py. We present the complete clinicopathologic features of this case wi th a review of the literature and discussion of the differential diagn osis.