ISOPROTERENOL INTERACTS DIFFERENTLY WITH BETA-ADRENOCEPTORS IN ASTROCYTES AND NEURONS ISOLATED FROM THE ADULT-RAT BRAIN

Authors
SAPENA R MORIN D ZINI R TILLEMENT JP
Citation
R. Sapena et al., ISOPROTERENOL INTERACTS DIFFERENTLY WITH BETA-ADRENOCEPTORS IN ASTROCYTES AND NEURONS ISOLATED FROM THE ADULT-RAT BRAIN, Biochemical pharmacology, 47(2), 1994, pp. 175-178
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
47
Issue
2
Year of publication
1994
Pages
175 - 178
Database
ISI
SICI code
0006-2952(1994)47:2<175:IIDWBI>2.0.ZU;2-5
Abstract
The interaction of isoproterenol with beta-adrenoceptors has been inve stigated in astroglial and neuronal cells isolated from adult rat cere bral cortices. Using the non-selective beta-adrenergic antagonist (H-3 )CGP-12177 as a ligand, binding experiments revealed that both types o f cells exhibit beta-adrenoceptors. However the analysis of the isopro terenol displacement curve indicated that only neuronal cells containe d the high affinity conformational state of the beta-adrenoceptor.