LONG-TERM ORAL-ADMINISTRATION OF ALUMINUM IN MICE - ALUMINUM DISTRIBUTION IN TISSUES AND EFFECTS ON CALCIUM-METABOLISM

Authors
ANGHILERI LJ MAINCENT P THOUVENOT P
Citation
Lj. Anghileri et al., LONG-TERM ORAL-ADMINISTRATION OF ALUMINUM IN MICE - ALUMINUM DISTRIBUTION IN TISSUES AND EFFECTS ON CALCIUM-METABOLISM, Annals of clinical and laboratory science, 24(1), 1994, pp. 22-26
Citations number
19
Categorie Soggetti
Medical Laboratory Technology
Journal title
Annals of clinical and laboratory science → ACNP
ISSN journal
00917370
Volume
24
Issue
1
Year of publication
1994
Pages
22 - 26
Database
ISI
SICI code
0091-7370(1994)24:1<22:LOOAIM>2.0.ZU;2-9
Abstract
Six months of oral administration of aluminum lactate provokes an impo rtant accumulation of aluminum in various tissues of mice. The accumul ation magnitude order is spleen > kidney > brain > liver > blood. No s ystemic toxic effects (weight loss or neurolytic effects) were observe d. Values of calcium content and Ca-45-uptake by the different tissues showed no modifications of calcium metabolism. The lack of calcium ho meostasis modification caused by a probable aluminum insolubilization, and the incidence of other individual factors on individual deviation s from group behavior is discussed.