PROGNOSTIC VALUE OF CEREBROSPINAL-FLUID NEURON-SPECIFIC ENOLASE AND S-100B PROTEIN IN GUILLAIN-BARRE-SYNDROME

We measured the cerebrospinal fluid (CSF) concentrations of neuron-spe cific enolase (NSE) and S-100b protein (S-100b) using enzyme immunoass ay methods, in 24 patients with Guillain-Barre syndrome and 46 control s, and examined their prognostic values. Sixteen of 24 patients showed elevated levels (> the mean + 2SD levels of controls) of NSE, S-100b, or both, and in those with higher NSE or S-100b levels there was a ra ther longer duration of disease, whereas 8 patients with the normal le vels showed an early recovery. Further, NSE or S-100b levels were sign ificantly correlated with months to recovery. Thus, NSE and S-100b in CSF may be useful markers for predicting the outcome of Guillain-Barre syndrome.