LACK OF BOTH SPINAL-FLUID OLIGOCLONAL BANDS AND COMPLEMENT 4A-PROTEININ AN MS PATIENT

Authors
FRANCIOTTA D PICCOLO G CUCCIA M BERGAMASCHI R ZARDINI E DERIL GVM DONDI E COSI V
Citation
D. Franciotta et al., LACK OF BOTH SPINAL-FLUID OLIGOCLONAL BANDS AND COMPLEMENT 4A-PROTEININ AN MS PATIENT, Acta neurologica Scandinavica, 89(1), 1994, pp. 72-74
Citations number
13
Categorie Soggetti
Clinical Neurology
Journal title
Acta neurologica Scandinavica → ACNP
ISSN journal
00016314
Volume
89
Issue
1
Year of publication
1994
Pages
72 - 74
Database
ISI
SICI code
0001-6314(1994)89:1<72:LOBSOB>2.0.ZU;2-I
Abstract
We report the case of a multiple sclerosis (MS) patient without oligoc lonal bands (OCB) in three cerebrospinal fluid samples. Restriction fr agment length polymorphism analysis of Class 3 genes with radiolabelle d specific cDNA probes showed a homozygous deletion of the complement 4A (C4A) genes. Consequent lack of C4A protein can alter the developme nt of humoral immune response probably preventing OCB production. Our observation may suggest a link between a rare immunogenetic pattern an d the absence of OCB in MS.