IDENTIFICATION OF A RELATED GROUP OF STREPTOCOCCUS-PNEUMONIAE ISOLATES WITH AN APPARENT HIGHER-MOLECULAR-WEIGHT PBP 3 USING PBP GENE FINGERPRINT ANALYSIS

Authors
CHALKLEY LJ
Citation
Lj. Chalkley, IDENTIFICATION OF A RELATED GROUP OF STREPTOCOCCUS-PNEUMONIAE ISOLATES WITH AN APPARENT HIGHER-MOLECULAR-WEIGHT PBP 3 USING PBP GENE FINGERPRINT ANALYSIS, Medical microbiology letters, 3(1), 1994, pp. 23-30
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
3
Issue
1
Year of publication
1994
Pages
23 - 30
Database
ISI
SICI code
1018-4627(1994)3:1<23:IOARGO>2.0.ZU;2-Z
Abstract
A group of 20 South African Streptococcus pneumoniae strains isolated between 1978-1988 (MICs 0.015-0.5 mug/ml) which possesses a HMW PBP 3 was investigated using PBP 1A, 2B and 2X gene fingerprinting. Similar PBP 2B and 2X fingerprints were found with 17 of 18 isolates with MICs of 0.125-0.5 mg/l, and 13 strains examined produced similar PBP IA fi ngerprints. It is epidemiologically interesting how such intermediatel y-resistant strains have persisted without further PBP gene diversity.