METAL-COMPLEXES OF BENZODIAZEPINES - KINETIC-PROPERTIES OF BROMAZEPAMTOWARD SQUARE-PLANAR DIMETHYL-SULFOXIDE COMPLEXES OF PLATINUM(II) ANDPALLADIUM(II)

Authors
CUSUMANO M GIANNETTO A MINNITI D
Citation
M. Cusumano et al., METAL-COMPLEXES OF BENZODIAZEPINES - KINETIC-PROPERTIES OF BROMAZEPAMTOWARD SQUARE-PLANAR DIMETHYL-SULFOXIDE COMPLEXES OF PLATINUM(II) ANDPALLADIUM(II), Inorganica Chimica Acta, 215(1-2), 1994, pp. 41-45
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Inorganica Chimica Acta → ACNP
ISSN journal
00201693
Volume
215
Issue
1-2
Year of publication
1994
Pages
41 - 45
Database
ISI
SICI code
0020-1693(1994)215:1-2<41:MOB-KO>2.0.ZU;2-U
Abstract
The kinetics of substitution reactions of Me(2)SO from the complexes [ MX(2)(Me(2)SO)(2)] (M=Pt, X=Cl CH3, cis; M=Pd, X=Cl, trans) by the lig ands bromazepam or bipy have been investigated in Me(2)SO and/or CH2Cl 2 at 25 degrees C. The results are interpreted in terms of an associat ive mechanism for cis-[PtCl2(Me(2)SO)(2)] and a dissociative mechanism for cis-[PtMe(2)(Me(2)SO)(2)]. The substitution reaction for the comp lex trans-[PdCl2(Me(2)SO)(2)] proceeds without retention of stereochem istry; a consecutive displacement mechanism or a pseudo-rotation mecha nism can be operative. The kinetic behaviour of bromazepam and bipy is very similar.