BIASED REPRESENTATION OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SUBGROUPS IN CHRONIC LYMPHOCYTIC-LEUKEMIA

Authors
HAKIM I AMARIGLIO N BROKSIMONI F GROSSMAN Z RAMOT B BENBASSAT I RECHAVI G
Citation
I. Hakim et al., BIASED REPRESENTATION OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SUBGROUPS IN CHRONIC LYMPHOCYTIC-LEUKEMIA, Israel journal of medical sciences, 30(1), 1994, pp. 7-9
Citations number
13
Categorie Soggetti
Medicine, General & Internal
Journal title
Israel journal of medical sciences → ACNP
ISSN journal
00212180
Volume
30
Issue
1
Year of publication
1994
Pages
7 - 9
Database
ISI
SICI code
0021-2180(1994)30:1<7:BROIHV>2.0.ZU;2-G
Abstract
The distribution of three immunoglobulin heavy chain variable region g ene subgroups (V(H)1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leuk emia. Thirty-seven patients displayed rearrangements of one of the abo ve three gene segments. Over-representation of the V(H)5 subgroup was observed relative to its small size.