ASYMMETRIC-SYNTHESIS OF CHIRAL FLUORINATE D COMPOUNDS

The synthesis of chiral compounds having fluorine atoms has become an important part of organofluorine chemistry in connection with analytic al, biological and medicinal chemistry and opto-electric substances su ch as liquid crystals. This review is focused on asymmetric synthesis of chiral compounds having a fluorine atom or a fluoroalkyl group (esp ecially a trifluoromethyl group). The examples cited in this review ar e divided in three different types; (a) asymmetric monofluorination, ( b) asymmetric fluoroalkylation (trifluoromethylation), and (c) convers ion from prochiral fluorinated compounds.