2,3-DIPHOSPHOGLYCERIC ACID BLOCKS LONG-TERM POTENTIATION OF EXCITATORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL CA1 NEURONS OF THE RAT

Citation
T. Behnisch et Kg. Reymann, 2,3-DIPHOSPHOGLYCERIC ACID BLOCKS LONG-TERM POTENTIATION OF EXCITATORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL CA1 NEURONS OF THE RAT, Neuroscience letters, 165(1-2), 1994, pp. 23-26
Citations number
30
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
03043940
Volume
165
Issue
1-2
Year of publication
1994
Pages
23 - 26
Database
ISI
SICI code
0304-3940(1994)165:1-2<23:2ABLPO>2.0.ZU;2-D
Abstract
The dependence of long-term potentiation on an intact inositol 1,4,5-t risphosphate [Ins(1,4,5)P-3] metabolism was investigated with the whol e-cell voltage-clamp method in the CA1 region of hippocampal slices. T he intracellular application of 2,3-diphosphoglyceric acid (1 mM), an inhibitor of the Ins(1,4,5)P-3 5-phosphatase and of Ins(1,4,5)P-3 3-ki nase eliminated the potentiation of postsynaptic currents in pyramidal cells 30 min after paired pre- and postsynapitc activation. These dat a suggest a possible role of postsynaptic inositol 1,4-bisphosphate an d/or inositol 1,3,4,5-tetra-kisphosphate in synaptic plasticity.