T. Behnisch et Kg. Reymann, 2,3-DIPHOSPHOGLYCERIC ACID BLOCKS LONG-TERM POTENTIATION OF EXCITATORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL CA1 NEURONS OF THE RAT, Neuroscience letters, 165(1-2), 1994, pp. 23-26
The dependence of long-term potentiation on an intact inositol 1,4,5-t
risphosphate [Ins(1,4,5)P-3] metabolism was investigated with the whol
e-cell voltage-clamp method in the CA1 region of hippocampal slices. T
he intracellular application of 2,3-diphosphoglyceric acid (1 mM), an
inhibitor of the Ins(1,4,5)P-3 5-phosphatase and of Ins(1,4,5)P-3 3-ki
nase eliminated the potentiation of postsynaptic currents in pyramidal
cells 30 min after paired pre- and postsynapitc activation. These dat
a suggest a possible role of postsynaptic inositol 1,4-bisphosphate an
d/or inositol 1,3,4,5-tetra-kisphosphate in synaptic plasticity.