ENHANCEMENT OF NMDA TOXICITY AND CALCIUM RESPONSES BY CHRONIC EXPOSURE OF CULTURED CORTICAL-NEURONS TO ETHANOL

Authors
AHERN KV LUSTIG HS GREENBERG DA
Citation
Kv. Ahern et al., ENHANCEMENT OF NMDA TOXICITY AND CALCIUM RESPONSES BY CHRONIC EXPOSURE OF CULTURED CORTICAL-NEURONS TO ETHANOL, Neuroscience letters, 165(1-2), 1994, pp. 211-214
Citations number
29
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
165
Issue
1-2
Year of publication
1994
Pages
211 - 214
Database
ISI
SICI code
0304-3940(1994)165:1-2<211:EONTAC>2.0.ZU;2-7
Abstract
Exposure of rat cerebrocortical cultures to 100 mM ethanol for 3-4 day s increased both the neurotoxic potency of N-methyl-D-aspartate (NMDA) and the maximal extent of NMDA-induced intracellular calcium (Ca-i(2)) elevations. In both control and ethanol-treated cultures, NMDA toxi city correlated closely with [Ca2+](i). Enhancement of NMDA responses may reflect neuronal adaptation to chronic ethanol exposure and could contribute to the pathogenesis of alcohol-related neurologic disorders .