A MECHANISTIC EVALUATION FOR THE RESOLUTION OF ENANTIOMERS OF ALPHA-ARYLPROPIONIC ACID-DERIVATIVES ON PI-BASIC CHIRAL STATIONARY PHASES

Authors
HYUN MH CHO SM RYOO JJ KIM MS
Citation
Mh. Hyun et al., A MECHANISTIC EVALUATION FOR THE RESOLUTION OF ENANTIOMERS OF ALPHA-ARYLPROPIONIC ACID-DERIVATIVES ON PI-BASIC CHIRAL STATIONARY PHASES, Journal of liquid chromatography, 17(2), 1994, pp. 317-328
Citations number
28
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of liquid chromatography → ACNP
ISSN journal
01483919
Volume
17
Issue
2
Year of publication
1994
Pages
317 - 328
Database
ISI
SICI code
0148-3919(1994)17:2<317:AMEFTR>2.0.ZU;2-I
Abstract
A chiral recognition mechanism involving face to edge pi-pi: interacti on for the separation of the two enantiomers of the 3,5-dinitroanilide derivatives of nonsteroidal anti-inflammatory drugs(NSAIDs) on chiral stationary phase(CSP) 1 has been proposed. The inverse chromatographi c resolution trends observed in resolving the two enantiomers of the 3 ,5-dinitroanilide derivatives of alpha-phenylalkanoic acids and alpha- (p-alkylphenyl)propionic acids on CSP 1 and 2 may support the postulat ed chiral recognition mechanism.