ORG-2766 PREVENTS DISRUPTION OF VESTIBULAR COMPENSATION BY AN NMDA RECEPTOR ANTAGONIST

The adrenocorticotrophic hormone fragment 4-9 (ACTH-(4-9)) analog, Org 2766 has been shown to accelerate vestibular compensation. However, N -methyl-D-aspartate (NMDA) receptor antagonists disrupt the recovery p rocess. When Org 2766 was administered at a dose of 20 nmol/kg every 4 h for 52 h, it prevented the disruption of compensation usually produ ced by a single 5 mg/kg i.p. injection of the NMDA receptor antagonist 3-([+]-2-carboxy-piperazin-4yl)-propyl-1-phos acid (CPP). NMDA recept or antagonists and ACTH-like peptides may produce their effects on com pensation by acting directly or indirectly at the same receptor comple x.