AEROSOLIZED AMPHOTERICIN B-LIPOSOMES FOR TREATMENT OF SYSTEMIC CANDIDA INFECTIONS IN MICE

Mice lethally infected with Candida albicans were exposed to small-par ticle aerosols containing amphotericin B-liposomes. The drug, when adm inistered twice daily for 2 h (0.58 mg/kg of body weight per day) on d ays 1, 2, and 3 postinoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the surv ival time of mice given 2 2-h treatments once a week for 4 weeks. A tw ice-weekly, 2-h small-particle aerosol administration of amphotericin B-liposomes for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.