ANTIBACTERIAL SYNERGISM OF POLYMYXIN-B NONAPEPTIDE AND HYDROPHOBIC ANTIBIOTICS IN EXPERIMENTAL GRAM-NEGATIVE INFECTIONS IN MICE

Citation
I. Ofek et al., ANTIBACTERIAL SYNERGISM OF POLYMYXIN-B NONAPEPTIDE AND HYDROPHOBIC ANTIBIOTICS IN EXPERIMENTAL GRAM-NEGATIVE INFECTIONS IN MICE, Antimicrobial agents and chemotherapy, 38(2), 1994, pp. 374-377
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
38
Issue
2
Year of publication
1994
Pages
374 - 377
Database
ISI
SICI code
0066-4804(1994)38:2<374:ASOPNA>2.0.ZU;2-8
Abstract
Polymyxin B nonapeptide, derived by cleavage of the fatty acyl diamino butyric acid from polymyxin B, is considerably less toxic, lacks bacte ricidal activity, and retains its ability to render gram-negative bact eria susceptible to several antibiotics by permeabilizing their outer membranes. The peptide rendered all 53 polymyxin-susceptible strains t ested more susceptible to novobiocin, lowering the MIC of novobiocin e ightfold or more. The combination of polymyxin B nonapeptide with novo biocin or with erythromycin administered intraperitoneally in multiple doses synergistically protected mice infected with gram-negative bact eria. This combination may be clinically useful because of the apparen t rarity of the acquisition of resistance.