IDENTIFICATION OF TEM-26 BETA-LACTAMASE RESPONSIBLE FOR A MAJOR OUTBREAK OF CEFTAZIDIME-RESISTANT KLEBSIELLA-PNEUMONIAE

Authors
URBAN C MEYER KS MARIANO N RAHAL JJ FLAMM R RASMUSSEN BA BUSH K
Citation
C. Urban et al., IDENTIFICATION OF TEM-26 BETA-LACTAMASE RESPONSIBLE FOR A MAJOR OUTBREAK OF CEFTAZIDIME-RESISTANT KLEBSIELLA-PNEUMONIAE, Antimicrobial agents and chemotherapy, 38(2), 1994, pp. 392-395
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
2
Year of publication
1994
Pages
392 - 395
Database
ISI
SICI code
0066-4804(1994)38:2<392:IOTBRF>2.0.ZU;2-Q
Abstract
An epidemic of nosocomial ceftazidime-resistant Klebsiella pneumoniae was correlated with production of a ceftazidime-hydrolyzing enzyme wit h an isoelectric point of 5.6 (BMH-1). BMH-1 was encoded on a large tr ansferable plasmid conferring multiple antibiotic resistance. The gene that encodes BMH-1 was identical to the gene that encodes the TEM-26 extended-spectrum beta-lactamase.