The objective of this study was to compare glycemic thresholds for hyp
oglycemic responses in obese and control subjects. A modified glucose-
clamp technique was used to produce a standardized fall in plasma gluc
ose (0.5 mmol/l per 40 min) in nine morbidly obese and ten control sub
jects. The release of the counterregulatory hormones was measured and
a symptom questionnaire was filled out every 10 min.