MODERN MULTIDIMENSIONAL PROTEIN NMR-SPECTROSCOPY .1. RESONANCE ASSIGNMENT METHODS

Authors
ZUIDERWEG ERP VANDOREN SR
Citation
Erp. Zuiderweg et Sr. Vandoren, MODERN MULTIDIMENSIONAL PROTEIN NMR-SPECTROSCOPY .1. RESONANCE ASSIGNMENT METHODS, TrAC. Trends in analytical chemistry, 13(1), 1994, pp. 24-36
Citations number
54
Categorie Soggetti
Chemistry Analytical
Journal title
TrAC. Trends in analytical chemistry → ACNP
ISSN journal
01659936
Volume
13
Issue
1
Year of publication
1994
Pages
24 - 36
Database
ISI
SICI code
0165-9936(1994)13:1<24:MMPN.R>2.0.ZU;2-O
Abstract
Nuclear magnetic resonance spectroscopy (NMR) methods to study protein s have in the last five years moved from two-dimensional proton-only t echniques to three- and four-dimensional triple- and quadruple-resonan ce techniques. The new methods allow more and more precise information to be extracted for the three-dimensional structure determination of the proteins in solution. This review focuses on these new techniques in relation to the assignment of NMR lines to the individual nuclei in the molecule.