I. Saito et al., INCREASED URINARY DOPAMINE EXCRETION IN YOUNG-PATIENTS WITH ESSENTIAL-HYPERTENSION, Clinical and experimental hypertension, 16(1), 1994, pp. 29-39
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy","Cardiac & Cardiovascular System
The evidence that some older patients with essential hypertension have
low urinary dopamine excretion has brought into question the levels o
f urinary dopamine and plasma dopa, the major source of urinary dopami
ne, in young patients with essential hypertension. Twentyfour-hour uri
ne sodium, creatinine, dopamine and noradrenaline and plasma dopa were
evaluated in 48 patients with essential hypertension aged 18 to 27 ye
ars and 25 normotensive subjects. In comparison with age-matched normo
tensive subjects, the hypertensive patients had higher urinary dopamin
e (1920 +/- 80 vs 1520 +/- 130 nmol/day, p < 0.01) and noradrenaline (
216 +/- 11 vs 179 +/- 12 nmol/day, p < 0.05) excretion. There was a si
gnificant correlation between urinary dopamine and noradrenaline excre
tion. There was no difference in plasma dopa levels between normotensi
ve and hypertensive subjects. These results suggest that the elevated
conversion of dopa to dopamine in the kidney is leading to increased u
rinary dopamine excretion in young patients with essential hypertensio
n.