AMOXICILLIN CONCENTRATION IN PUS FROM ABSCESS CAUSED BY ODONTOGENIC INFECTION

1. Amoxicillin concentration in pus from odontogenic infection was ass ayed and the concentrations were compared with MIC (minimum inhibitory concentration) of alpha-hemolytic streptococci isolated from odontoge nic infection. 2. Measurable amoxicillin concentrations in serum and p us were found in all instances (n = 16). 3. The mean peak concentratio ns in serum and pus were found at identical times, 1.5 hr after admini stration, which were 5.92 and 0.90 mu g/ml, respectively. 4. The mean concentration ratio of pus/serum the at the peak time was 0.15. 5. All amoxicillin concentrations in pus at the peak time exceeded the MIC f or 90% of alpha-hemolytic streptococci (0.25 mu g/ml).