EFFECT OF ARABINOSYLCYTOSINE DERIVATIVE CYCLOCYTIDINE ON HEPATAL FUNCTIONS IN RATS AND ON ZAJDELA-HEPATOMA

1. The effectivity of the arabinosylcytosine (araC) derivative, cycloc ytidine (cC), against Zajdela hepatoma was evaluated. It was establish ed that the cC effect was dose-dependent. 2. Zajdela hepatoma-bearing rats, given a single dose of 500 mg of cC per kg of body weight, showe d an increased life span of 48 and 39%. 3. cC significantly decreased the number of Zajdela hepatoma cells in ascitic fluid and affected the cytochrome content in hepatal mitochondria. 4. The overall cC effect on the hepatal function of normal and hepatectomized liver was margina l, thus making this araC derivative an interesting candidate for furth er evaluation of its effectivity against non-hematological tumors.