AGGRESSIVE GRANULAR LYMPHOCYTE LEUKEMIA OF NATURAL-KILLER-CELL TYPE IN AN ELDERLY PATIENT

Authors
ICHIKAWA N KITANO K HIGUCHI M KOBAYASHI H TERADA N SHIMODAIRA S SONOYAMA M INOUE M KAWA K FURUTA S
Citation
N. Ichikawa et al., AGGRESSIVE GRANULAR LYMPHOCYTE LEUKEMIA OF NATURAL-KILLER-CELL TYPE IN AN ELDERLY PATIENT, Internal medicine, 32(11), 1993, pp. 882-885
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
Internal medicine → ACNP
ISSN journal
09182918
Volume
32
Issue
11
Year of publication
1993
Pages
882 - 885
Database
ISI
SICI code
0918-2918(1993)32:11<882:AGLLON>2.0.ZU;2-0
Abstract
A 75-year-old man was admitted to our hospital because of intermittent fever. His peripheral blood picture showed granular lymphocyte (GL) p roliferation. The GLs were immunologically and functionally phenotyped as natural killer cells. Chromosomal analysis of peripheral lymphocyt es with interleukin-2 stimulation revealed an inversion of chromosome 9 with an unusual breakpoint, showing abnormal monoclonal proliferatio n of the GLs. Progressive increase of GL count and hepatosplenomegaly necessitated the start of combined chemotherapy. His condition was com plicated by icterus and renal failure, and he died finally of respirat ory failure. Autopsy revealed disseminated intravascular coagulation a nd infiltration of GLs in the bone marrow, spleen, and liver.