THE DETERMINATION OF DIETHYLSTILBESTROL (DES) IN THE FECES AND TISSUES OF CHICKENS TREATED WITH DES AND IN THE FECES AND TISSUE SAMPLES OF CALVES, LAMBS AND CHICKENS COLLECTED FROM VARIOUS AREAS OF TURKEY

Diethylstilbestrol (DES) analyses were carried out on muscle, liver, k idney and faeces samples of 20 control and 20 experimental broilers to which 5 mg DES/day had been given orally for a period of 7 days. The treated samples were analysed using the Radioimmunoassay method. The r emoval time of DES from the tissues was determined. Five days followin g the final administration of DES, its faecal concentration was 151 pp b. However, 7 days after the final administration faecal DES concentra tions increased again. On the first day after the final DES administra tion, DES concentrations in the liver, muscle and kidney were 0.78, 0. 74 and 1.33 ppb, respectively. While these values measured on the fina l day were within the range of the control values. There was an increa se of DES in plasma at the end of the experimental period. A total of 1811 muscle, liver, kidney and faeces samples of calves, lambs and chi ckens and feed samples collected from various areas in Turkey were ana lysed for the presence of DES. Positive samples for chicken feed was 3 6.9 %. Also 1.9 % of the chicken faeces samples were DES positive. All other samples were negative for DES.