METABOLITES OF EBROTIDINE, A NEW H-2-RECEPTOR ANTAGONIST, IN HUMAN URINE

Authors
ROZMAN E GALCERAN MT ANGLADA L ALBET C
Citation
E. Rozman et al., METABOLITES OF EBROTIDINE, A NEW H-2-RECEPTOR ANTAGONIST, IN HUMAN URINE, Journal of pharmaceutical sciences, 83(2), 1994, pp. 252-254
Citations number
13
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
83
Issue
2
Year of publication
1994
Pages
252 - 254
Database
ISI
SICI code
0022-3549(1994)83:2<252:MOEANH>2.0.ZU;2-9
Abstract
Ebrotidine is a new H-2-receptor antagonist which exhibits a remarkabl e ability for gastric mucosal protection. A preliminary metabolic path way for this compound was proposed and the hypothetic metabolites were synthesized. The presence of ebrotidine and its metabolites ebrotidin e S-oxide and 4-bromobenzenesulfonamide in human urine has been confir med by HPLC separation and spectroscopic characterization of the colle cted fractions by FT-IR and H-1 NMR. Ebrotidine S,S-dioxide has been i dentified by HPLC using diode-array detection.