Pr. Karmakar et al., PLACEBO-CONTROLLED IMMUNOTHERAPY WITH COCOS-NUCIFERA POLLEN EXTRACT, International archives of allergy and immunology, 103(2), 1994, pp. 194-201
The effectiveness of Cocos nucifera pollen extract immunotherapy (CPE-
IT) was studied in 96 patients allergic to C. nucifera pollen. A place
bo-controlled study was performed at random for a period of 6-12 month
s. The clinical status of the patients measured by the symptom-medicat
ion scores demonstrated that C. nucifera pollen-allergic patients had
significant (p < 0.005) clinical improvement after CPE-IT in compariso
n to placebo treatment. Serological study resulted a significant reduc
tion (p < 0.001) of specific IgE and significant elevation (p < 0.01)
of specific IgG in post-therapeutic patients' sera which were correlat
ed significantly (r = 0.45, p < 0.001); the changes of the above immun
oglobulin levels in the placebo-treated patients were nonsignificant.
However, there was no correlation between symptom-medication scores an
d changes in specific serum IgE or IgG levels.