Ignition in a laminar supersonic mixing layer between two parallel str
eams of initially separated reactants is studied both numerically and
through the use of large activation energy asymptotics. The asymptotic
analysis provides a description of ignition characteristics over the
entire range of system parameters. In particular, it is demonstrated t
hat, for small values of viscous heating, the ignition distance scales
approximately Linearly with the freestream Mach number, whereas for l
arge viscous heating it decreases rapidly due to the temperature-sensi
tive nature of the reaction rate. This indicates the potential of usin
g local flow retardation to enhance ignition rather than relying solel
y on external heating. The asymptotic analysis further identifies seve
ral distinct ignition situations, yielding results that compare well w
ith those obtained from the full numerical calculation. The effects of
flow nonsimilarity are also assessed and are found to be more promine
nt for the mixing layer flow in comparison to the flat-plate configura
tion studied previously.