INTRATHECAL SYNTHESIS OF IGG IN SIMIAN IMMUNODEFICIENCY VIRUS (SIV)-INFECTED RHESUS MACAQUES (MACACA-MULATTA)

Citation
Mo. Smith et al., INTRATHECAL SYNTHESIS OF IGG IN SIMIAN IMMUNODEFICIENCY VIRUS (SIV)-INFECTED RHESUS MACAQUES (MACACA-MULATTA), AIDS research and human retroviruses, 10(1), 1994, pp. 81-89
Citations number
53
Categorie Soggetti
Immunology,"Infectious Diseases
ISSN journal
08892229
Volume
10
Issue
1
Year of publication
1994
Pages
81 - 89
Database
ISI
SICI code
0889-2229(1994)10:1<81:ISOIIS>2.0.ZU;2-1
Abstract
We examined cerebrospinal fluid (CSF) and serum from 25 simian immunod eficiency (SIV)-infected rhesus macaques for the presence of SIV-speci fic immunoglobulin G (IgG) and for intrathecal synthesis of IgG. SIV-s pecific IgG was present in CSF from almost 50% of the macaques. In app roximately half of these animals the SIV-specific IgG appeared to be d erived from serum by leakage across a disrupted blood-brain barrier, w hereas in the remaining animals there was evidence of intrathecal IgG synthesis. There were no significant associations between CSF SIV-spec ific IgG, intrathecal IgG synthesis and isolation of virus from CSF, c linical status, or neuropathological findings. However, SIV-specific I gG was absent from CSF in all four of the macaques with SIV encephalit is. The presence of SIV-specific IgG in CSF may have a modulating effe ct on the development of SIV-associated neurological disease.