Se. Wilkinson et Tj. Hallam, PROTEIN-KINASE-C - IS ITS PIVOTAL ROLE IN CELLULAR ACTIVATION OVER-STATED, Trends in pharmacological sciences, 15(2), 1994, pp. 53-57
Evidence has emerged over the past decade to suggest that protein kina
se C (PKC) is a widespread family of kinases responsible for many dive
rse and critical cellular Junctions. With the development of selective
agents to activate or inhibit the individual PKC isoenzymes, it is no
w apparent that much of the literature that implicated PKC in many cel
lular functions needs to be appraised. In this article, Sandra Wilkins
on and Trevor Hallam discuss the problems of the existing methods and
the recent evidence that suggests that PKC isotypes are necessary for
some, but not all, of those cellular responses where PKC had been thou
ght to play an important role. Selective inhibitors of PKC isoenzymes
may have potential for therapeutic use in auto-immune diseases, transp
lant rejection and oncology.