PROTEIN-KINASE-C - IS ITS PIVOTAL ROLE IN CELLULAR ACTIVATION OVER-STATED

Citation
Se. Wilkinson et Tj. Hallam, PROTEIN-KINASE-C - IS ITS PIVOTAL ROLE IN CELLULAR ACTIVATION OVER-STATED, Trends in pharmacological sciences, 15(2), 1994, pp. 53-57
Citations number
45
Categorie Soggetti
Pharmacology & Pharmacy
Volume
15
Issue
2
Year of publication
1994
Pages
53 - 57
Database
ISI
SICI code
Abstract
Evidence has emerged over the past decade to suggest that protein kina se C (PKC) is a widespread family of kinases responsible for many dive rse and critical cellular Junctions. With the development of selective agents to activate or inhibit the individual PKC isoenzymes, it is no w apparent that much of the literature that implicated PKC in many cel lular functions needs to be appraised. In this article, Sandra Wilkins on and Trevor Hallam discuss the problems of the existing methods and the recent evidence that suggests that PKC isotypes are necessary for some, but not all, of those cellular responses where PKC had been thou ght to play an important role. Selective inhibitors of PKC isoenzymes may have potential for therapeutic use in auto-immune diseases, transp lant rejection and oncology.