Cognitive theories of depression have proposed that negative attitudes
about the self are activated either by recent life events or by the e
xperience of depression itself, and contribute either to the onset or
the course of the disorder, or to both. However, attitudinal measures
have been relatively unsuccessful in predicting in advance who is like
ly to become depressed. In contrast, biographical details of childhood
and recent adversity are relatively powerful predictors of depression
onset. Other recent research has found that depressed patients often
experience high levels of repeated intrusive memories of specific inst
ances of adversity. Both reports of abuse, as well as intrusion and av
oidance of memories of this abuse, are related to the production of ov
er-general memories on an autobiographical memory test and to other me
asures of depressive attitudes and cognitions. These findings suggest
that depression may be intimately connected with the emotional process
ing of memories of specific traumatic or stressful events. They direct
attention to the processes whereby memories of trauma may be both act
ivated and inhibited for relatively long periods, and suggest new ther
apeutic possibilities for prevention of onset and relapse.