AGING AND ACETYLCHOLINE-RELEASE BY TITYUSTOXIN FROM BRAIN CORTICAL SLICES

Authors
QUEIROZ IB TURCHETTIMAIA RMM MORAESSANTOS T GOMEZ MV
Citation
Ib. Queiroz et al., AGING AND ACETYLCHOLINE-RELEASE BY TITYUSTOXIN FROM BRAIN CORTICAL SLICES, Toxicon, 32(2), 1994, pp. 232-234
Citations number
12
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
32
Issue
2
Year of publication
1994
Pages
232 - 234
Database
ISI
SICI code
0041-0101(1994)32:2<232:AAABTF>2.0.ZU;2-9
Abstract
The ability of tityustoxin to trigger acetylcholine release was studie d in cerebral cortical slices from 2, 12 and 23-month-old rats. The ef fect of tityustoxin to induce the release of acetylcholine was reduced by 60% in senescent animals. This result suggests that ageing reduces the sensitivity of cerebral cortical nerve terminals to tityustoxin.