ASYMMETRIC HYDROLYSIS OF CHIRAL NITRILES BY RHODOCOCCUS-RHODOCHROUS NCIMB-11216 NITRILASE

Authors
GRADLEY ML KNOWLES CJ
Citation
Ml. Gradley et Cj. Knowles, ASYMMETRIC HYDROLYSIS OF CHIRAL NITRILES BY RHODOCOCCUS-RHODOCHROUS NCIMB-11216 NITRILASE, Biotechnology letters, 16(1), 1994, pp. 41-46
Citations number
6
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
16
Issue
1
Year of publication
1994
Pages
41 - 46
Database
ISI
SICI code
0141-5492(1994)16:1<41:AHOCNB>2.0.ZU;2-L
Abstract
The enantioselective potential of Rhodococcus rhodochrous NCIMB 11216 nitrilase has been measured, using a range of chiral nitriles with var ious C-2 group substitutions. The highest selectivity was achieved dur ing the biotransformation of (+/-) 2-methylhexanitrile where the react ion appears enantiospecific for the (+) enantiomer.