SYNTHESIS OF SUBSTITUTED 2-AMINONICOTINON ITRILES

Authors
TROSCHUTZ R DENNSTEDT T
Citation
R. Troschutz et T. Dennstedt, SYNTHESIS OF SUBSTITUTED 2-AMINONICOTINON ITRILES, Archiv der pharmazie, 327(1), 1994, pp. 33-40
Citations number
30
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
1
Year of publication
1994
Pages
33 - 40
Database
ISI
SICI code
0365-6233(1994)327:1<33:SOS2I>2.0.ZU;2-S
Abstract
Mono-, di-, and trisubstituted 2-aminonicotinonitriles 8, 13, 14, and 19 are prepared from ketonic Mannich-bases hydrochlorides 4 . HCl, eno nes 12, beta-aminovinylketones 17, 3 aminoacroleines 18, vinamidinium perchlorates 21, and 3,3 diaminoacrylonitrile (3). generated in situ. 3 is further reacted with 4 . HCl in the presence of ammonium acetate to yield the tetrahydro-1.8 naphthyridines 10.