EARLY LYMPHOID BLASTIC CRISIS FOLLOWING MAJOR KARYOTYPIC CONVERSION IN A CHRONIC MYELOID-LEUKEMIA PATIENT TREATED WITH INTERFERON-ALPHA

Authors
AMBROSETTI A KRAMPERA M VENERI D MENEGHINI V APRILI F MARTINELLI G PIZZOLO G PERONA G
Citation
A. Ambrosetti et al., EARLY LYMPHOID BLASTIC CRISIS FOLLOWING MAJOR KARYOTYPIC CONVERSION IN A CHRONIC MYELOID-LEUKEMIA PATIENT TREATED WITH INTERFERON-ALPHA, International journal of clinical & laboratory research, 24(1), 1994, pp. 58-59
Citations number
10
Categorie Soggetti
Medicine, Research & Experimental
Journal title
International journal of clinical & laboratory research → ACNP
ISSN journal
09405437
Volume
24
Issue
1
Year of publication
1994
Pages
58 - 59
Database
ISI
SICI code
0940-5437(1994)24:1<58:ELBCFM>2.0.ZU;2-9
Abstract
A major karyotypic conversion following interferon-alpha treatment del ays or prevents blastic crisis in patients with chronic myeloid leukem ia. We report here a 12-year-old boy with Ph1+ chronic myeloid leukemi a who, after achieving a major karyotypic conversion following 12 mont hs interferon-alpha treatment, developed an early lymphoid blastic tra nsformation 7 months later while still under interferon-alpha therapy. A number of possible explanations for this quite unexpected event are discussed.