Whether for hepatic trauma or transplantation, a surgeon's knowledge o
f hepatic anatomy commonly determines a patient's outcome. The first m
edically relevant anatomic studies of the liver emerged with the endea
vors of Herophilus and Erasistratus between 310 and 250 BC. Yet it was
not until after the development of anesthesia and antisepsis that the
first formal resections were performed during the late 1800s. After v
ascular occlusion principles had been developed as a means of successf
ul hemorrhage control, several deliberate attempts were made to repair
the fiver surgically. Such efforts culminated in the work of Wendel i
n 1910 when he followed avascular planes during hepatectomy. The funct
ional anatomy of surgery and surgical technique had suddenly joined in
an effort to advance the practice, and eventually the efficacy of hep
atic surgeons in facilitating the modern era of segmental anatomy exte
nded hepatectomies and transplantation surgery.