EFFECT OF ASPIRIN ON LIPID-PEROXIDATION IN EXPERIMENTAL MYOCARDIAL-INFARCTION IN RATS

In myocardial necrosis induced by isoproterenol, a marked increase in serum iron content and significant decrease in plasma iron binding cap acity, ceruloplasmin activity, and glutathione level were observed The increase in phospholipase activity and lipid peroxides level, with lo wering of glutathione peroxidase, glutathione-S-transferase, catalase, and superoxide dismutase activities observed in isoproterenol treatme nt may lead to the excessive formation of free radicals, resulting in cardiac cell damage. Aspirin, an antithrombotic agent, showed a marked reversal of these metabolic changes related to ischaemia induced by i soproterenol.