L. Sarma et al., EVALUATION OF RADIOPROTECTIVE ACTION OF A MUTANT (E-25) FORM OF CHLORELLA-VULGARIS IN MICE, Journal of radiation research, 34(4), 1993, pp. 277-284
The possible role of orally fed Chlorella vulgaris (E-25) in modulatin
g the gamma-ray induced chromosomal damage in whole-body irradiated mi
ce was evaluated using a micronucleus test. Different doses of E-25 we
re administered either chronically (once, twice or thrice a day for 28
days) or as single acute doses before/after irradiation. A significan
t radioprotective effect was observed in both acute and chronic pretre
atments, but only at doses above 400 mg/kg body weight. However, in mi
ce that received E-25 (500 mg/kg) three times a day for 28 days, there
was no protective effect, and a significant loss in their body weight
was observed. Interestingly, E-25 afforded significant radioprotectio
n even when it was administered within 0.4 hr after irradiation.