FACTORS MODIFYING THE RISK OF ACUTE AND CONDITIONED NAUSEA AND VOMITING IN OVARIAN-CANCER PATIENTS

We prospectively studied, how certain patient characteristics modify t he risk of chemotherapy induced and conditioned nausea and vomiting. Y oung age and previous history of nausea and vomiting were factors asso ciated with both chemotherapy induced nausea and vomiting as well as c onditioned nausea. Conditioned nausea was significantly associated wit h having received two-day compared to one-day mode of chemotherapy, pr evious distress during blood samples and odor memory. Tentative associ ations were also found between a history of flushing and chemotherapy induced nausea and vomiting as well as between autonomic perception, o dor associations and conditioned nausea. The investigated variables ex plained a larger part of the variance in conditioned compared acute na usea and vomiting.