IN-VITRO ACTIVITY OF RUFLOXACIN AGAINST LISTERIA-MONOCYTOGENES, LEGIONELLA-PNEUMOPHILA, AND CHLAMYDIA-TRACHOMATIS

The in vitro activity of a new fluorquinolone, rufloxacin, was determi ned against both clinical isolates and standard strains of Legionella pneumophila, Chlamydia trachomatis, and Listeria monocytogenes and com pared to that of ciprofloxacin, ofloxacin, and erythromycin. Among the antibacterials tested erythromycin was the most active. Rufloxacin in hibited the growth of L. pneumophila at concentrations in the range of 0.06-0.25 mg/l, that of C. trachomatis at concentrations in the range of 2-4, and that of L. monocytogenes at concentrations in the range o f 1-2 mg/l. Rufloxacin demonstrated approximately the same activity as ciprofloxacin against C. trachomatis, but twice as less potency as of loxacin and erythromycin against L. pneumophila, L. monocytogenes, and C. trachomatis, and twice as less potency as ciprofloxacin against L. pneumophila.