ASSIGNMENT OF THE GENE ENCODING THE LATENT TGF-BETA-1-BINDING PROTEIN(LTBP1) TO HUMAN-CHROMOSOME-2, REGION P12-]Q22

Authors
STENMAN G SAHLIN P OLOFSSON A VANKESSEL AG MIYAZONO K
Citation
G. Stenman et al., ASSIGNMENT OF THE GENE ENCODING THE LATENT TGF-BETA-1-BINDING PROTEIN(LTBP1) TO HUMAN-CHROMOSOME-2, REGION P12-]Q22, Cytogenetics and cell genetics, 66(2), 1994, pp. 117-119
Citations number
17
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
66
Issue
2
Year of publication
1994
Pages
117 - 119
Database
ISI
SICI code
0301-0171(1994)66:2<117:AOTGET>2.0.ZU;2-H
Abstract
Latent transforming growth factor beta 1-binding protein (LTBP1) is an important component of the large latent TGF-beta 1 complex. It plays a role in the assembly and secretion of the latent TGF-beta 1. In this paper we have used a cDNA probe for LTBP1 to determine the chromosoma l localization of the human gene. Using a panel of well-defined human x rodent somatic cell, hybrid lines, LTBP1 could be assigned to chromo some 2. Further sublocalization of the gene to 2p12-->q22 was achieved using three hybrid lines which contain partially overlapping fragment s of chromosome 2.