CELL-CYCLE-STAGE SPECIFICITY OF THE METHOTREXATE BLOCK AS RESOLVED BYX-RAY-INDUCED CHROMOSOME-DAMAGE

Authors
RICHARDSON VB LITTLEFIELD LG SAYER AM PETERSON PT
Citation
Vb. Richardson et al., CELL-CYCLE-STAGE SPECIFICITY OF THE METHOTREXATE BLOCK AS RESOLVED BYX-RAY-INDUCED CHROMOSOME-DAMAGE, Cytogenetics and cell genetics, 66(2), 1994, pp. 126-128
Citations number
10
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
66
Issue
2
Year of publication
1994
Pages
126 - 128
Database
ISI
SICI code
0301-0171(1994)66:2<126:CSOTMB>2.0.ZU;2-D
Abstract
Radiation-induced chromosome aberrations were used as biomarkers to co mpare G(0), mid-G(1), and methotrexate (MTX)-arrested lymphocytes. The ratio of chromosome-type to chromatid-type aberrations in MTX-arreste d cells was consistent with that predicted when postreplicative chromo somes are exposed to ionizing radiation and supports the premise that MTX arrests cells in late S/G(2) of the cell cycle.