The extradural dead space produced after enlargement of the intracrani
al space or after reduction of the volume of the intracranial contents
persists for an unknown period of time. To investigate this further,
an extradural dead space was surgically created by advancement of pari
etal bones in 9 adult rabbits. By design, there was no connection with
the paranasal sinuses. To determine outcome of the dead space, three-
dimensional computed tomographic and histological studies were perform
ed. The brain volume decreased in the first 3 months after surgery and
remained constant for up to 9 months. The extradural volume increased
in the first 4 weeks postoperatively, gradually decreasing in size wi
th time. The brain failed to eliminate the extradural dead space by re
arrangement or expansion. An osseous cavity filled with fluid and conn
ective tissue was formed within the dead space. The fluid within it re
mained, even 9 months after surgery. This could be a potential environ
ment for bacterial invasion if there was a connection with the nasopha
rynx.