AT LEAST 3 GENES ARE RESPONSIBLE FOR BENOMYL-RESISTANCE IN METARHIZIUM-ANISOPLIAE

Four benomyl-resistant mutants isolated from Metarhizium anisopliae we re 10 to 500 times more resistant than the original MT strain. The res istance markers analysed in three of these mutants were due to a three different mutations and no additive effect of these genes was observe d in double mutants. The four mutants presented normal conidiation in the presence or absence of benomyl and no sensitivity or resistance to temperature. Probably M. anisopliae has a mechanism of benomyl resist ance differing from those of Aspergillus nidulans and Neurospora crass a.