Since there have been a few reports of pediatric HIV-2 infection. We t
herefore investigated the perinatal transmission of HIV-2 in 147 malno
urished and 164 well-nourished children attending a health center in t
he northern part of Guinea Bissau. Specific HIV-2 antibodies were dete
cted in 17 mothers and in 2 malnourished children, one of them with pe
diatric AIDS. This study demonstrates that mother to child transmissio
n of HIV-2 infection occurs in Guinea Bissau and suggests that there i
s an increased likelihood of detecting HIV-2 infection in malnourished
children. The high seroprevalence of HIV-2 in a rural population with
out known risk factors may represent a hidden threat to mother/child h
ealth.