SECONDARY SOLID MALIGNANT-TUMORS OCCURRING AFTER BONE-MARROW TRANSPLANTATION FOR SEVERE APLASTIC-ANEMIA GIVEN THORACOABDOMINAL IRRADIATION

Authors
PIERGA JY SOCIE G GLUCKMAN E DEVERGIE A HENRYAMAR M BRIDIER A GIRINSKY T NGUYEN J COSSET JM
Citation
Jy. Pierga et al., SECONDARY SOLID MALIGNANT-TUMORS OCCURRING AFTER BONE-MARROW TRANSPLANTATION FOR SEVERE APLASTIC-ANEMIA GIVEN THORACOABDOMINAL IRRADIATION, Radiotherapy and oncology, 30(1), 1994, pp. 55-58
Citations number
20
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Journal title
Radiotherapy and oncology → ACNP
ISSN journal
01678140
Volume
30
Issue
1
Year of publication
1994
Pages
55 - 58
Database
ISI
SICI code
0167-8140(1994)30:1<55:SSMOAB>2.0.ZU;2-0
Abstract
PURPOSE: We have evaluated irradiation doses received at location of s econdary solid tumors occurring after bone marrow transplantation (BMT ) in five of 147 patients grafted for severe aplastic anaemia. RESULTS : All 5 tumors occurred within the radiation field penumbra. The estim ated received dose varied from 6 Gy for one inner field secondary tumo r, to 2.5 Gy for the remaining secondary tumors. CONCLUSION: Tumors ma y arise in the zone where the delivered radiation dose drops dramatica lly. Irradiation, with associated cofactors, may promote the developme nt of epidermoid carcinoma in irradiated patients for BMT.