Klatskin tumors often pose a challenge for diagnosis and treatment. Mo
st of these neoplasms are diagnosed clinically because of the difficul
ty in obtaining tissue that will provide histologic proof of the disea
se. When a nonoperative course is sought, exhaustive attempts should b
e made to obtain a tissue diagnosis because of the potential for a fal
se-positive clinical diagnosis. We describe a new way to obtain tissue
for diagnosis by placing a laparoscopic choledochoscope through a per
cutaneous transhepatic cholangiogram track, thus allowing the tumor to
be directly visualized and biopsied.