Laparoscopic resection of a giant retroperitoneal, mesenteric cyst in
a 38-year-old man who presented with abdominal distension and pedal ed
ema is described. The diagnosis was made by abdominal computed tomogra
phy, which revealed a large cystic mass that was causing extrinsic com
pression of the inferior vena cava and the right ureter. The hospital
course was uneventful, and the patient was discharged 2 days postopera
tively. This new endoscopic approach offers a useful alternative to th
e traditional transabdominal excision of a mesenteric cyst and may hav
e some theoretical advantages, including less postoperative pain and s
horter convalescence.