MAPPING IN THE REGION OF DANFORTHS SHORT TAIL AND THE LOCALIZATION OFTAIL LENGTH MODIFIERS

We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth' s short tail (Sd). The map includes 14 simple sequence repeat (SSR) ma rkers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localiz e quantitative trait loci (QTL) that modify the tail length of Sd prog eny of the backcross. This has allowed us to identify a major QTL on c hromosome 10 in the region of of nodal and three other putative tail l ength QTL on chromosomes 1, 9, and 18.