SILICON TETRACHLORIDE SODIUM-IODIDE AS A DEBLOCKING AGENT FOR T-BUTOXYCARBONYL GROUP IN SOLID-PHASE PEPTIDE-SYNTHESIS

Deprotection of t-butoxycarbonyl group during solid phase synthesis of peptides can be conveniently and efficiently carried out using a nonh ydrolytic and neutral reagent, silicon tetrachloride-sodium iodide (io dotrichlorosilane). The method is simple and rapid. The synthesis of a pentapeptide fragment (Tyr-Ile-Gly-Ser-Arg-NH2) of laminin, a basemen t membrane specific glycoprotein, has thus been carried out in good yi eld and high purity.