IN-VITRO EFFECTS OF BRODIMOPRIM ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS - PRELIMINARY-RESULTS

Authors
MINI E NOVELLI A CORONNELLO M FALLANI S PESCIULLESI A PERITI P
Citation
E. Mini et al., IN-VITRO EFFECTS OF BRODIMOPRIM ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS - PRELIMINARY-RESULTS, Journal of chemotherapy, 5(6), 1993, pp. 499-501
Citations number
NO
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Journal of chemotherapy → ACNP
ISSN journal
1120009X
Volume
5
Issue
6
Year of publication
1993
Pages
499 - 501
Database
ISI
SICI code
1120-009X(1993)5:6<499:IEOBOH>2.0.ZU;2-Y
Abstract
The in vitro effects of brodimoprim and trimethoprim on the functions of human polymorphonuclear (PMN) leukocytes have been studied comparat ively evaluating chemotaxis, phagocytosis and production of superoxide anion. No significant effects of both diaminopyrimidines on chemotaxi s and phagocytic activity of PMNs have been observed while both brodim ioprim and trimethoprim enhanced the oxidative burst. A synergistic ac tivity between the host immune system and the direct antimicrobial act ion of brodimoprim may occur while using this diaminopyrimidine in viv o.