A MULTICENTER COMPARATIVE-STUDY OF BRODIMOPRIM AND AMOXICILLIN THERAPY IN THE TREATMENT OF TONSILLOPHARYNGITIS IN ADULTS

Study objective: To compare the efficacy and safety of brodimoprim (BD P) with those of amoxicillin (AMX) in patients with acute bacterial ph aryngitis/tonsillitis. Design: Randomized controlled study. Setting: H ospital and general practices in Austria, Germany and Switzerland. Pat ients: 519 adult patients of both sexes aged 12 to 75 years. Intervent ion: Patients were allocated to an 8- to 12-day treatment with BDP (40 0 mg loading dose followed by 200mg once a day) or AMX (750mg t.i.d). Main outcome measures: Resolution of clinical signs/ symptoms and nega tive bacterial examination at completion of therapy. Results: Clinical cure/improvement rate of 97.8% and 94.8% in respectively the BDP and the AMX group. Bacterial eradication in 87.7% of the cases treated wit h BDP and 88.3% of those receiving AMX. Very good/good tolerability in 85.2% BDP- and 82.8% AMX treated patients.